FIGURE 8 from WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers
Year: 2024
Type: other
Abstract: WNT4 variant genotype is associated with metabolic remodeling in gynecologic tumors, mirroring ILC signaling. A–C, Points represent total network score for the listed RPPA targets for individual tumors based on rs3820282 genotype. Red bar = median score; P-value from Mann–Whitney t test. A, Tumor scores for AMPK-associated network. B, Tumor scores for phospho-AMPK only. C, Tumor scores for glucose metabolism-associated network. D, Scatterplot of network scores in A and C; correlation from full dataset, that is, WT and Var samples combined. E–G, Network scores as in A–C from n = 58 stage I endometrioid-type endometrial tumors; networks generated independently from full dataset. E, Tumor scores for metabolic signaling network associated with AMPK and lipid metabolism signaling. F, Tumor scores for phospho-AMPKα1 only. G, Tumor scores for glucose metabolism-associated network. H, Points represent AMPK network score for individual tumors based on rs3820282 genotype and race/ethnicity groups. *, adj.P < 0.1, ANOVA with Welch correction. Cells were transfected with siRNA for 72 hours prior to immunoblotting, with ovarian cancer cell lines (I) and ILC cell lines (J). Representative band from total protein staining shown as loading control.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4390943774