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FIGURE 6 from WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers

Year: 2024
Type: other
Abstract: Consensus WNT4-regulated metabolites are enriched for fatty acid metabolism. A, Consensus of n = 41 metabolites rescued with WNT4-OE and metabolites inversely regulated by WNT4-OE versus WNT4 knockdown. WNT4 ON versus OFF corresponds to differential regulation by WNT4 overexpression versus knockdown, respectively. B, Pathway analysis of consensus WNT4-regulated metabolites. C, Gene set enrichment analysis of genes differentially expressed in Luminal A ILC versus Luminal A IDC (n = 1360) includes metabolic pathways, with relative gene expression levels in ILC consistent with increased lipid metabolism and decreased glycolysis and OXPHOS. Points = individual genes (fold changes from TCGA, ref. 7); red bar = median fold change. D, fGSEA = fast gene set enrichment analysis of representative pathways in C. NES = normalized enrichment score.
DOI: 10.1158/2767-9764.25012813
Authors: Joseph L. Sottnik, Madeleine T. Shackleford, Sydney K. Robinson, Fabian R. Villagomez, Shaymaa Bahnassy, Steffi Oesterreich, Junxiao Hu, Zeynep Madak-Erdogan, Rebecca B. Riggins, Bradley R. Corr, Linda S. Cook, Lindsey S. Treviño, Benjamin G. Bitler, Matthew J. Sikora
Language: English
Open Access status: gold
OpenAlex ID: W4390944277
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