The role of the peripheral system dysfunction in the pathogenesis of sepsis-associated encephalopathy
Year: 2024
Type: article
Abstract: Sepsis is a condition that greatly impacts the brain, leading to neurological dysfunction and heightened mortality rates, making it one of the primary organs affected. Injury to the central nervous system can be attributed to dysfunction of various organs throughout the entire body and imbalances within the peripheral immune system. Furthermore, central nervous system injury can create a vicious circle with infection-induced peripheral immune disorders. We collate the pathogenesis of septic encephalopathy, which involves microglial activation, programmed cell death, mitochondrial dysfunction, endoplasmic reticulum stress, neurotransmitter imbalance, and blood-brain barrier disruption. We also spotlight the effects of intestinal flora and its metabolites, enterocyte-derived exosomes, cholinergic anti-inflammatory pathway, peripheral T cells and their cytokines on septic encephalopathy.
Source: Frontiers in Microbiology
Authors: Jingyu Zhang, Shuangli Chen, Xiyou Hu, Lihong Huang, PeiYong Loh, Xinru Yuan, Zhen Liu, Jinyu Lian, Lianqi Geng, Zelin Chen, Yi Guo, Bo Chen
Institution: Tianjin University of Traditional Chinese Medicine
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,295
OpenAlex ID: W4390953157