Work

Low ectonucleotidase activity and increased neutrophil-platelet aggregates in patients with antiphospholipid syndrome

Year: 2024

Type: article

Abstract: ABSTRACT: Many patients with antiphospholipid syndrome had decreased ectonucleotidase activity on neutrophils and platelets, which enabled extracellular nucleotides to trigger neutrophil-platelet aggregates. This phenotype was replicated by treating healthy neutrophils and platelets with patient-derived antiphospholipid antibodies or ectonucleotidase inhibitors.

Source: Blood

DOI: 10.1182/blood.2023022097

Authors: Somanathapura K. NaveenKumar, Ajay Tambralli, Bruna Mazetto Fonseca, Srilakshmi Yalavarthi, Wenying Liang, Claire K. Hoy, Cyrus Sarosh, Christine E. Rysenga, Caroline H. Ranger, Caroline E. Vance, Jacqueline A. Madison, Fernanda A. Orsi, Suman L. Sood, Jordan K. Schaefer, Yu Zuo, Jason S. Knight

Institutions: University of Michigan, Universidade Estadual de Campinas (UNICAMP), Michigan Medicine

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G306146036, G7433697189

OpenAlex ID: W4390964520

FWCI: 2.774

Cites: 16

Cited by: 10

Related to: 10