Year: 2024
Type: editorial
Abstract: Platelets are anucleate cells that serve as primary guardians of vascular integrity by initiating hemostasis and tissue repair in response to vascular injury 1 .Derived from megakaryocytes, platelets are endowed with approximately 5-10 mitochondria, which are essential for launching such injury responses, and for maintaining their short lifespan of 7-10 days. 2 Despite being short lived, platelet protective responses are required to maintain mitochondrial integrity and function.In the absence of a nucleus that actively provide transcripts for mitochondria biogenesis, dynamic processes, such as mitochondrial fusion and fission, along with mitochondrial transcripts, are needed to maintain cellular bioenergetics and function.Mitochondrial fusion, conserved from yeast to humans, is a complex active protective process that merges 2 or more mitochondria (within minutes), and exchanges mtDNA, proteins, lipids and other molecules between mitochondria.3 An early study suggested that mitochondrial fusion can occur in vitro in a cell free state 4 .Whether
Source: Circulation Research
Institution: Yale University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G143768663, Platelets in vascular injury repair, Yale Cooperative Center of Excellence in Hematology, Platelet mitochondrial function in health and disease, Yale Clinical and Translational Science Award, Age-dependent heterogeneity in the efficacy of prophylaxis with enoxaparin against catheter-associated thrombosis in critically ill children
OpenAlex ID: W4390967871