Work

Lithocholic acid derivatives as potent modulators of the nuclear receptor RORγt

Year: 2024

Type: article

Abstract: ) value of 225 ± 10.4 nM. Unlike 3-oxo-lithocholic acid, A2 demonstrated the ability to reduce the IL-17A mRNA expression levels in EL4 cells with RORγt expression using quantitative reverse transcriptase PCR (RT-PCR). Validation of the desirable physicochemical properties and stability of A2 sets the stage for the preclinical evaluation of this new class of RORγt modulators in animal models of autoimmune diseases.

Source: RSC Advances

DOI: 10.1039/d3ra08086b

Authors: Somaya A. Abdel-Rahman, Simone Brogi, Moustafa T. Gabr

Institutions: Mansoura University, Weill Cornell Medicine, University of Pisa

Language: English

Topic: Psoriasis: Treatment and Pathogenesis

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042