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FIGURE 2 from FASN Gene Methylation is Associated with Fatty Acid Synthase Expression and Clinical-genomic Features of Prostate Cancer

Year: 2024

Type: other

Abstract: FASN protein expression in tumor glands is inversely correlated with FASN gene methylation in tumor tissue in primary prostate tumors. A, Representative plots of beta values (range: 0–1) by FASN probe on InfiniumEPIC for three tumors among the lowest (blue, H-score range from 3–4) and highest (red, H-score range from 289–292) mean FASN protein expression in the JHU cohort. Mean FASN beta values are negatively correlated with FASN protein levels by immunostaining for tumors in JHU cohort (B) and with FASN protein levels by RPPA in TCGA cohort (C). Each point in B and C represents an individual tumor.

DOI: 10.1158/2767-9764.25020894

Authors: Oluwademilade Dairo, Lia DePaula Oliveira, Ethan Schaffer, Thiago Vidotto, Adrianna A. Mendes, Jiayun Lu, Sophie Vo Huynh, Jessica Hicks, Adam G. Sowalsky, Angelo M. De Marzo, Corrine E. Joshu, Brian Hanratty, Karen S. Sfanos, William B. Isaacs, Michael C. Haffner, Tamara L. Lotan

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4391011722

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