Advances in Microsphere-Based Super-Resolution Imaging
Year: 2024
Type: review
Abstract: Techniques to resolve images beyond the diffraction limit of light with a large field of view (FOV) are necessary to foster progress in various fields such as cell and molecular biology, biophysics, and nanotechnology, where nanoscale resolution is crucial for understanding the intricate details of large-scale molecular interactions. Although several means of achieving super-resolutions exist, they are often hindered by factors such as high costs, significant complexity, lengthy processing times, and the classical tradeoff between image resolution and FOV. Microsphere-based super-resolution imaging has emerged as a promising approach to address these limitations. In this review, we delve into the theoretical underpinnings of microsphere-based imaging and the associated photonic nanojet. This is followed by a comprehensive exploration of various microsphere-based imaging techniques, encompassing static imaging, mechanical scanning, optical scanning, and acoustofluidic scanning methodologies. This review concludes with a forward-looking perspective on the potential applications and future scientific directions of this innovative technology.
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $2,495
Awards: Collaborative Research: Acoustic Holography Enabled Additive Manufacturing of High-resolution Multifunctional Composites, Three-Dimensional (3D) Acoustofluidic Scanning Nanoscope with Super Resolution and Large Field of View, Development of an acoustofluidic device for high-throughput 3D imaging and sorting of C. elegans, Integrated Acoustofluidic Plasmonic Molecular Diagnostic System for Detecting MicroRNA Biomarkers, Development of a multifunctional, acoustofluidic 3D bioprinter with single-cell resolution, Harmonic Acoustics for Neighboring cell Dynamic studies(HANDs)
OpenAlex ID: W4391020028