Work

Contrasting Evolution After Withdrawal of Long-Term Administration of Difelikefalin for CKD-Associated Pruritus

Year: 2024

Type: article

Abstract: Chronic kidney disease (CKD) associated pruritus (CKD-aP) is a very common condition in end-stage kidney disease under dialysis, affecting up to a third of the patients worldwide,1-2 with a significant impact of their quality of life.3 Until recently, therapeutic solutions were scarce and not very effective.4 The pathogenesis of CKD-aP is multifactorial, involving the accumulation of uremic toxins and inflammatory mediators, abnormal peripheral nerve conduction, and an imbalance between peripheral Mu opioid receptors (MORs) and Kappa opioid receptors (KORs).

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2024.01.019

Authors: Guy Rostoker, Antoine Lanot