Chemical Constituents from the Leaves of Dischidia nummularia (Asclepiadaceae)
Year: 2023
Type: article
Abstract: The investigation of chemical constituents from Dischidia nummularia leaves, which belongs to the Asclepiadaceae family, resulted in five known compounds. Three compounds were suggested as triterpenoid derivatives, namely glutinol (1), α-amyrin (2) and friedelin (3). In addition, two other compounds were a steroid derivative (4), i.e., stigmast-5-ene-3β-ol (4) and a xanthone derivative, i.e., α-mangostin (5). The chemical structures of 1–5 were elucidated based on detailed analysis of NMR (1D and 2D) spectroscopic data and compared with literature data. Interestingly, compounds 1 and 5 were first obtained from the Asclepiadaceae family, while compound 2 was isolated for the first time from the Dischidia genus. The acetone crude extract and compounds 1–3 showed weak cytotoxicity against murine leukemia P-388 cells. After all, the current study is the first report of a phytochemical study of D. nummularia.
Source: Natural Product Sciences
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4391038137