Therapeutic targeting of KRAS mutation-driven tumorigenesis by extracellular vesicles loaded with small interfering RNA
Year: 2024
Type: preprint
Abstract: RAS is a well-known oncogene contributing to significant proportion of cancer incidences, yet it remains as an undruggable target to majority of therapeutic modalities. Here, we explored the potential of extracellular vesicles (EVs) for therapeutic targeting of KRAS mutation-driven tumorigenesis. EVs loaded with small interfering RNA (siRNA) against KRAS successfully inhibited tumor xenograft growth when injected intratumorally in mice models. Intriguingly, when injected intravenously, EVs were still able to accumulate in tumors and deliver KRAS targeting siRNA payload in sufficient amount to show tumor growth inhibition. Therefore, EV-siRNA platform show great promises for therapeutic targeting of KRAS mutations and other undruggable targets.
Authors: Yanhua Zhai, Shuiqin Niu, Tao Qiu, Yuan Yi, Yu Yan, Rui Hu, Xinjun He, Ke Xu
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4391044398