Work

PINK1 knockout rats show premotor cognitive deficits measured through a complex maze

Year: 2024

Type: article

Abstract: Cognitive decline in Parkinson’s disease (PD) emerges up to 10 years before clinical recognition. Neurobiological mechanisms underlying premotor cognitive impairment in PD can potentially be examined in the PINK1 -/- rat, which exhibits a protracted motor onset. To enhance translation to human PD cognitive assessments, we tested a modified multiple T-maze, which measures cognitive flexibility similarly to the Trail-Making Test in humans. Like human PD outcomes, PINK1 -/- rats made more errors and took longer to complete the maze than wild types. Thus, we have identified a potential tool for assessing cross-species translation of cognitive functioning in an established PD animal model.

Source: Frontiers in Neuroscience

DOI: 10.3389/fnins.2024.1390215

Authors: Isabel Soto, Vicki A. Nejtek, David P. Siderovski, Michael F. Salvatore

Institution: University of North Texas Health Science Center

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295