Reviewed the Research Strategy and Progress of SARS-CoV-2 Live Attenuated Vaccine Under the Global Omicron Epidemic Trend
Year: 2024
Type: article
Abstract: Since the continuous mutation of SARS-CoV-2, it became new challenges to the global COVID-19 epidemic, including vaccine prevention and treatment. Because of the global pandemic Omicron strain, which had been dominant epidemic strain, the new innovative vaccine had been improved into an important field, by global scientists. Live attenuated vaccines (LAV) had played a key role in the global action plan to eliminate polio, measles and other important infectious diseases. Additionally, LAV had advanced practical experience in the prevention and control of animal coronaviruses. So the LAV of SARS-CoV-2 should be seriously considered as a useful and important way. In this review, it analyzed its necessity from coronavirus serotype and epidemic R0 trend, and studied its feasibility from the application of animal coronavirus LAV. Herein, it focused on the four kinds of SARS-CoV-2 LAV that had completed their preclinical studies, COVI-VAC, d16, CPD and VAS5. Regarding their design principles, the growth characteristics of attenuated strains, their safety and immunogenicity in animal model and their cross-protection effects, these were all analyzed and discussed. So, the SARS-CoV-2 LAV had a solid theoretical and practical foundation, base on the modern vaccinology and genomics progress.
Source: Medical Research Frontiers
Authors: Liu Ze, Huang Jinhai, Gao Hui
Institution: Tianjin University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4391051970