Work

Author Response: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

Year: 2024

Type: peer-review

Abstract: An enhanced bioinformatic pipeline to quantify Plasmodium falciparum core gene and polymorphic var gene expression revealed changes occurring during early culture adaptation of parasites from naturally infected individuals.

Source: eLife

DOI: 10.7554/elife.87726.3.sa4

Authors: Clare Andradi-Brown, Jan Stephan Wichers-Misterek, Heidrun von Thien, Yannick D Höppner, Judith Anna Marie Scholz, Helle Smedegaard Hansson, Emma Filtenborg Hocke, Tim Wolf Gilberger, Michael Duffy, Thomas Lavstsen, Jake Baum, Thomas D Otto, Aubrey J Cunnington, Anna Bachmann

Institutions: Imperial College London, Bernhard Nocht Institute for Tropical Medicine, University of Copenhagen, The University of Melbourne, University of Glasgow

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: Wellcome Trust, National Institute for Health and Care Research, Imperial College London, Deutsche Forschungsgemeinschaft, NIHR Imperial Biomedical Research Centre

Awards: Epigenetische Regulation der Antigenvariation im Malariaerreger Plasmodium falciparum, Developing de-novo assembly tools to predict gene transcriptional markers of severe malaria disease and ways to prevent it, Analyse der Transkriptionsdynamik von Virulenzfaktoren in klinischen Isolaten des Malariaerregers Plasmodium falciparum, The cellular and molecular mechanics of malaria parasite invasion of the human erythrocyte., Wellcome Trust Centre for Molecular Parasitology., G4591806611, G5991770078, The cellular and molecular mechanics of malaria parasite invasion of the human erythrocyte., Developing de-novo assembly tools to predict gene transcriptional markers of severe malaria disease and ways to prevent it

OpenAlex ID: W4391220582

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