Work

Review of pre-metastatic niches in lung metastasis: From cells to molecules, from mechanism to clinics

Year: 2024

Type: review

Abstract: Distant metastasis is responsible for high mortality in most cancer cases and the lung is one of the most common target organs, severely affecting the quality of daily life and overall survival of cancer patients. With relevant research breakthroughs accumulating, scientists have developed a deeper understanding of lung metastasis (LM) from the rudimentary "seed and soil" theory to a more vivid concept of the pre-metastatic niche (PMN). Thus, the mechanisms of PMN formation become considerably complicated, involving various types of cells, chemokines, cytokines, and proteins, providing potential biomarkers for improved LM diagnosis and treatment techniques. Here we summarized the latest findings (in 3 years) of lung PMN and systematically collated it from basic research to clinical application, which clearly exhibited the influences of the primary tumor, stromal, and bone marrow-derived cells (BMDCs) and associated molecules in the formation of lung PMN.

Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

DOI: 10.1016/j.bbcan.2024.189081

Authors: Hongting Xie, Quan Sun, Xuelei Chu, Shijie Zhu, Feiyu Xie

Institutions: Wangjing Hospital of China Academy of Chinese Medical Sciences, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Zhejiang Cancer Hospital, University of Chinese Academy of Sciences

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,790