Work

Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2

Year: 2024

Type: article

Source: European Journal of Medicinal Chemistry

DOI: 10.1016/j.ejmech.2024.116154

Authors: Julia Velez, Brandon Dale, Kwang-Su Park, H. Ümit Kaniskan, Xufen Yu, Jian Jin

Institutions: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Icahn School of Medicine at Mount Sinai, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: G1477301087, An AVANCE NEO 600 MHz NMR Spectrometer System for Structural and Chemical Biology, G2297578197, G2425007192, Targeting Lysine Methyltransferases EZH2 and EZH1 for Treating MLL-rearranged Leukemias, (PQ9) Developing EZH2 Degraders for Treating Triple-Negative Breast Cancer, G3790433503, G3855817145, G7022274620, G770722518, An AVANCE NEO 400 MHz NMR Spectrometer for Chemical Biology and Drug Discovery, Training Program in Cancer Biology, G8605398129, G9000183751, G9000211592, G9000276032

OpenAlex ID: W4391265064

FWCI: 4.862

Cites: 48

Cited by: 42

Related to: 10