The perinucleolar compartment: structure, function, and utility in anti-cancer drug development
Year: 2024
Type: article
Abstract: The perinucleolar compartment (PNC) was initially identified as a nuclear structure enriched for the polypyrimidine tract-binding protein. Since then, the PNC has been implicated in carcinogenesis. The prevalence of this compartment is positively correlated with disease progression in various types of cancer, and its expression in primary tumors is linked to worse patient outcomes. Using the PNC as a surrogate marker for anti-cancer drug efficacy has led to the development of a clinical candidate for anti-metastasis therapies. The PNC is a multicomponent nuclear body situated at the periphery of the nucleolus. Thus far, several non-coding RNAs and RNA-binding proteins have been identified as the PNC components. Here, we summarize the current understanding of the structure and function of the PNC, as well as its recurrent links to cancer progression and metastasis.
Source: Nucleus
Authors: Eugene V. Makeyev, Sui Huang
Institutions: King's College London, Northwestern University
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,993
Awards: Understanding developmentally controlled co-transcriptional splicing in the mammalian nervous system, G3934757053, G4284711823, Understanding Nuclear RNA Quality Control in Mammalian Nervous System, The role of the nucleolus in human genome organization in normal and disease states, G4953086962, G5279907765, G5530357448, Understanding biological functions of repeat-containing noncoding RNAs
OpenAlex ID: W4391294086