Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female Hormones
Year: 2024
Type: article
Abstract: During female adolescence and pregnancy, rising levels of hormones result in a cyclic source of signals that control the development of mammary tissue. While such alterations are well understood from a whole-gland perspective, the alterations that such hormones bring to organoid cultures derived from mammary glands have yet to be fully mapped. This is of special importance given that organoids are considered suitable systems to understand cross species breast development. Here we utilized single-cell transcriptional profiling to delineate responses of murine and human normal breast organoid systems to female hormones across evolutionary distinct species. Collectively, our study represents a molecular atlas of epithelial dynamics in response to estrogen and pregnancy hormones.
Institutions: Cold Spring Harbor Laboratory, Stony Brook University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,890
Awards: Defining the cellular and molecular effects of aging and age of pregnancy on breast tissue homeostasis and cancer initiation, Probing the role of epigenomics in Brca1-deficient mammary tumors., G4373432326, G5753238768, G666505512, G9000279778, Blockade of cMYC oncogenic function by pregnancy-induced alterations and remodeling of the mammary gland, CSHL Cancer Center Support Grant
OpenAlex ID: W4391355045