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FIGURE 5 from A Revised Molecular Model of Ovarian Cancer Biomarker CA125 (MUC16) Enabled by Long-read Sequencing

Year: 2024

Type: other

Abstract: MUC16 model proposed in this study. The model includes: a highly glycosylated N-terminal domain, a 19-unit tandem repeat domain that contains the CA125 epitopes, and a short C-terminal domain that includes a membrane-spanning region. The inset shows a representative 3D structure of one tandem repeat domain, predicted by AlphaFold. The C-loop (residues 59–79) is shown in red, with the cysteine residues shown in salmon. The unstructured proline/serine/threonine-rich region is omitted for clarity. White slashes within the N-terminal domain and tandem repeat domain show locations where amino acids are not explicitly shown for clarity. Figure created with https://Biorender.com.

DOI: 10.1158/2767-9764.25118635.v1

Authors: Chien-Wei Wang, Simon D. Weaver, Nicha Boonpattrawong, Naviya Schuster-Little, Manish Patankar, Rebecca J. Whelan

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4391386293

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