Identification of C4BPA as biomarker associated with immune infiltration and prognosis in breast cancer
Year: 2024
Type: article
Abstract: Background: is regarded as a new biomarker for cancer, especially for non-small cell lung cancer and ovarian cancer. However, its role in breast cancer (BC) has not yet been determined. Methods: In this research, we used a bioinformatics approach to assess the prognostic significance of C4BPA in BC. Utilizing a variety of databases and analysis tools, including The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), R, STRING, and the Kaplan-Meier plotter, we specifically assessed the connection between C4BPA and BC. Results: expression might have worse PFI and OS in patients with Luminal A compared to other BC subtypes. Conclusions: could potentially act as a diagnostic biomarker for BC patients indicating unfavorable prognoses and offers valuable knowledge for creating therapeutics and prognostic indicators.
Source: Translational Cancer Research
DOI: 10.21037/tcr-23-1215
Authors: Juan Zou, Yaokun Chen, Zeqi Ji, Danyi Liu, Xin Chen, Mengjia Chen, Kexun Chen, Haojia Lin, Yexi Chen, Zhiyang Li
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4391390192