Year: 2024
Type: article
Abstract: The assessment of “omics” signatures may contribute to personalized medicine and precision nutrition. However, the existing literature is still limited in the homogeneity of participants’ characteristics and in limited assessments of integrated omics layers. Our objective was to use post-prandial metabolomics and fasting proteomics to identify biological pathways and functions associated with diet quality in a population of primarily Hispanic young adults. We conducted protein and metabolite-wide association studies and functional pathway analyses to assess the relationships between a priori diet indices, Healthy Eating Index-2015 (HEI) and Dietary Approaches to Stop Hypertension (DASH) diets, and proteins (n = 346) and untargeted metabolites (n = 23,173), using data from the MetaAIR study (n = 154, 61% Hispanic). Analyses were performed for each diet quality index separately, adjusting for demographics and BMI. Five proteins (ACY1, ADH4, AGXT, GSTA1, F7) and six metabolites (undecylenic acid, betaine, hyodeoxycholic acid, stearidonic acid, iprovalicarb, pyracarbolid) were associated with both diets (p < 0.05), though none were significant after adjustment for multiple comparisons. Overlapping proteins are involved in lipid and amino acid metabolism and in hemostasis, while overlapping metabolites include amino acid derivatives, bile acids, fatty acids, and pesticides. Enriched biological pathways were involved in macronutrient metabolism, immune function, and oxidative stress. These findings in young Hispanic adults contribute to efforts to develop precision nutrition and medicine for diverse populations.
Source: Nutrients
DOI: 10.3390/nu16030429
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,296
Awards: G1023978630, G1122572190, G1136537688, G1199430394, G1226273678, G125233966, G1292929380, G1323717370, G1480891745, G1583036818, G1603973469, G1673697537, G1697687765, G1756583213, G1758257229, G1774871685, G1875315801, G2282244144, G2337021182, G2437086363, G254430589, G2587071436, G2658428538, G2722741801, G2878536864, G2926640885, G293692451, G3180099256, Environmental Chemical Exposures and Longitudinal Changes of Glucose Metabolism, Insulin Sensitivity and B Cell Function in Youth, G344424179, G346198372, G3592400865, G3626700433, G3705176895, G3739233415, G3871635011, G3875184454, G4046419735, G4257847315, G4296988821, Developmental origins of child liver injury: Effects of prenatal environmental exposures, G4333290277, G4339145954, G4400230905, G4436301447, G4627905093, Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicals, G4864275471, G4892494616, G4898320502, G4964878182, G514464281, G5162058651, G5229491074, G5375579862, G5569704551, Metabolomic Signatures Linking Air Pollution, Obesity and Diabetes, G5809958103, G5999136682, G6402359648, G6489668101, G680112814, G6831150447, G7137192840, G7190582482, G7283239193, G7495004546, USC Research Center for Liver Disease, G7792395375, G7975447308, G8003510389, The adipose exposome effects on the plasma metabolome, body composition and metabolic outcomes after bariatric surgery, G8134862794, G8337655436, G8479680661, G8557816703, G8619016105, G8721570330, G8885962598, G89476839, Perfluoroalkyl Substances and the Gut Microbiome and Fecal Metabolome: Implications for Obesity Risk in Hispanic Children, G903130330, G979367543, G995621964
OpenAlex ID: W4391404199