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FIGURE 3 from Genome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses

Year: 2024

Type: other

Abstract: ∆Np63 and TAp63 control distinct biological processes by cooperating with different transcription factors. A, Venn diagrams of ΔNp63-specific, common, and TAp63-specific direct target genes, with p63 ChIP-seq peaks ± 10 kb from their genomic loci. B–D, List of the differentially enriched pathways in ΔNp63-specific, common, and TAp63-specific direct target genes. E, Table listing the top 10 differentially enriched motifs in the peaks ± 10 kb from ΔNp63-specific, common, and TAp63-specific direct target genes. Highlighted in yellow are the motifs of the transcription factors selected for validation.

DOI: 10.1158/2767-9764.25126733.v1

Authors: Marco Napoli, Avani A. Deshpande, Deepavali Chakravarti, Kimal Rajapakshe, Preethi H. Gunaratne, Cristian Coarfa, Elsa R. Flores

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4391449756

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