FIGURE 7 from Genome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses
Year: 2024
Type: other
Abstract: TAp63 promotes the NRF2-dependent oxidative stress response. A, Venn diagram of the differentially regulated genes in the indicated ΔNp63-competent versus deleted murine primary epithelial cell types. Listed are the pathways enriched in each respective section. B, Venn diagram of the differentially regulated genes in the indicated TAp63-competent versus deleted murine primary cell types. Listed are the pathways enriched in both epithelial cell types. C, Scatter plot of the metabolic pathways differentially regulated in WT versus TAp63−/− epidermal cells. Labeled are the NRF2-dependent metabolic pathways. D, Quantification of the CellRox signal in KER-CT cells transfected with the indicated siRNAs and treated with H2O2. The CellRox signal is normalized with respect to the siControl untreated cells. Data are mean ± SD, n = 8, * versus siControl H2O2, # versus siTAp63 H2O2, and $ versus siNRF2 H2O2, P < 0.005, two-tailed t test. E–R, Representative images of CellRox signal in KER-CT cells transfected with the indicated siRNAs and treated with H2O2. Scale bars, 100 µm.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4391449838