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PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression

Year: 2024
Type: article
DOI: 10.1016/j.cmet.2024.01.006
Authors: Xin Yang, Zhe Wang, Svetlana N. Samovich, Alexander A. Kapralov, Andrew A. Amoscato, Vladimir A. Tyurin, Haider H. Dar, Zhiming Li, Shoufu Duan, Ning Kon, Delin Chen, Benjamin Tycko, Zhiguo Zhang, Xuejun Jiang, Hülya Bayir, Brent R. Stockwell, Valerian E. Kagan, Wei Gu
Institutions: Herbert Irving Comprehensive Cancer Center, Columbia University, University of Pittsburgh, Columbia University Irving Medical Center, Hackensack Meridian Health, Memorial Sloan Kettering Cancer Center
Language: English
Field: Medicine
Open Access status: bronze
Funders: Herbert Irving Comprehensive Cancer Center, Columbia University, Foundation for the National Institutes of Health, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke
Awards: Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis, G379599081, G4151178790, G5238415042, Oxidative Lipidomics in Pediatric Traumatic Brain Injury, G5539976247, Mechanisms and Function of Autophagy in Cancer, G6412716416, G8381234687, Lipids and Myeloid Cell Function in Cancer, G9000010446, G9000093075, G9000094908, Cancer Center Support Grant, Oxidative Lipidomics in Pediatric Traumatic Brain Injury, Ferroptosis and Cancer Cell Signaling, Regulation of tumor recurrence by stress activated neutrophils, p53-mediated metabolic regulation in tumor suppression, Co-regulation of p53 and PD-L1 by the VPRBP-USP2 axis in transcription and ubiquitylation, Lipid Imaging in Traumatic Brain Injury by High Resolution GCIB-secondary Ion Mass Spectrometry, Novel small molecule USP7 Inhibitors for p53 activation and cancer therapy, Cancer Center Support Grant
OpenAlex ID: W4391470441
FWCI: 15.55
Cites: 80
Cited by: 60
Related to: 10