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Supplementary Figure 5 from Immune Modulation of Innate and Adaptive Responses Restores Immune Surveillance and Establishes Antitumor Immunologic Memory

Year: 2024

Type: supplementary-materials

Abstract: A. Cytolytic effect of VLV-GFP in cancer cells is mediated by the induction of pro-apoptotic genes. Treatment of cancer cells with VLV-GFP is associated with a significant increase on TRAIL and FAS mRNA expression. *=p>0.005; **= p>0.001 B. In vivo induction of pro-apoptotic genes. Mice bearing mCherry-TKO tumors were treated 2X with VLV-GFP. The expression of TRAIL and FAS was determined 24h after the last treatment. Note the significant increase on TRAIL and FAS mRNA expression following VLV-GFP treatment. ***= p>0.0001

DOI: 10.1158/2326-6066.25132784.v1

Authors: Ayesha B. Alvero, Alexandra Fox, Bhaskara Reddy Madina, Marie M. Krady, Radhika Gogoi, Hussein Chehade, Valerian Nakaar, Bijan Almassian, Timur O. Yarovinsky, Thomas Rutherford, Gil Mor

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4391483833

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