Work

Photoredox-Driven Three-Component Coupling of Aryl Halides, Olefins, and O 2

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Modern organic synthesis requires methodologies that bring together abundant feedstock chemicals in a mild and efficient manner. To aid in this effort, we have developed a multicomponent radical hydroxyarylation reaction that utilizes aryl halides, olefins, and O 2 as the reaction components. Crucial to this advance was an oxidative, rather than a reductive, approach to aryl radical generation, which enables reaction tolerance to O 2 . This methodology displays a broad functional group tolerance with a variety of functionalized aryl halides and a broad array of olefins. Development of this methodology enables rapid access to biologically relevant hydroxyaryl products from simple, commercially available starting materials.

Source: ACS Catalysis

DOI: 10.1021/acscatal.3c05988

Authors: Mark C. Maust, Simon B. Blakey

Institution: Emory University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500