Supplementary Tables 1 - 4 from Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression
Year: 2024
Type: supplementary-materials
Abstract: Supplementary Table 1: Raw read counts per gene for bulk RNA-seq IPI-926 intervention study. Raw read counts of matching biopsy (Bx) and necropsy (Nx) bulk RNA-seq samples after two days of treatment with vehicle or IPI-926. Supplementary Table 2: Digestion buffer for single cell preparation. List of reagents optimized for single cell digestion of KPC-derived tumors. Supplementary Table 3: Single Cell RNA-seq Quality Control. Overview of KPC-derived scRNA-seq samples, containing treatment information (vehicle or IPI-926; n=3 each), sequencing depth, detected genes, and detection of mitochondrial genes (MT%). Supplementary Table 4: Network sizes in murine scRNA-seq data. Number of regulatory proteins for which regulons were generated in each network type, in each cell type, from KPC mouse pancreatic tumors.
Authors: Marie C. Hasselluhn, Amanda R. Decker-Farrell, Lukas Vlahos, Dafydd H. Thomas, Alvaro Curiel-Garcia, H. Carlo Maurer, Urszula N. Wasko, Lorenzo Tomassoni, Stephen A. Sastra, Carmine F. Palermo, Tanner C. Dalton, Alice Ma, Fangda Li, Ezequiel J. Tolosa, Hanina Hibshoosh, Martin E. Fernandez-Zapico, Alexander Muir, Andrea Califano, Kenneth P. Olive
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4391650682