Year: 2024
Type: article
Abstract: INTRODUCTION: We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images. METHODS: We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke. RESULT: Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13-2.68) and 1.48 (95% CI, 1.12-1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04-2.42) for overall arteries and 2.11 (95% CI, 1.45-3.08) for basilar artery diameters > 95th percentile. DISCUSSION: Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.13712
Authors: Jesus D. Melgarejo, Kursat Gurel, Cassidy Rose Compton, Minghua Liu, Vanessa Guzman, Stephanie Assuras, Bonnie E. Levin, Mitchell S. V. Elkind, M. Kamran Ikram, Maryam Kavousi, M. Arfan Ikram, Clinton Wright, Fabrice Crivello, Alexandre Laurent, Christophe Tzourio, Meike W. Vernooij, Tatjana Rundek, Zhen‐Yu Zhang, Daniel Bos, Jose Gutierrez
Institutions: Erasmus MC, The University of Texas Rio Grande Valley, KU Leuven, Columbia University, University of Miami, National Institutes of Health, National Institute of Neurological Disorders and Stroke, Institut des Maladies Neurodégénératives, Université de Bordeaux, Inserm, Bordeaux Population Health
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
Funders: National Science Foundation, Sanofi, European Commission, Institut National de la Santé et de la Recherche Médicale, ZonMw, Erasmus Universiteit Rotterdam, Fondation pour la Recherche Médicale, KU Leuven, Fondation de France, Agence Française de Sécurité Sanitaire des Produits de Santé, Mutuelle Générale de l'Education Nationale, National Institutes of Health, National Institute on Aging, National Institute of Neurological Disorders and Stroke
Awards: G3077373795, Vascular Determinants of Dementia and Cognitive Decline in a Tri-Ethnic Region, G48410712, G5462254239, Genetic Contribution to Brain Arterial Dilatation and its Role in Cognition and dementia, G600890823, Accelerated non-atherosclerotic brain arterial aging relationship to Alzheimer's disease, G8769603600, G987742920
OpenAlex ID: W4391687045