Per- and Polyfluoroalkyl Substances (PFAS) in Serum of 2 to 5 year-Old Children: Temporal Trends, Determinants, and Correlations with Maternal PFAS Concentrations
Year: 2024
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Young children may experience higher per- and polyfluoroalkyl substances (PFAS) exposure than adults due to breastfeeding, higher dust ingestion rates, and frequent hand-to-mouth activities. We explored temporal trends and determinants of child serum PFAS concentrations and their correlations with paired maternal PFAS concentrations. From 2009 to 2017, we collected one blood sample from each of 541 children aged 2–5 years participating in the Childhood Autism Risks from Genetics and Environment (CHARGE) study and quantified 14 PFAS in serum. For nine frequently detected PFAS (>65% of samples), we performed multiple regression adjusting for potential determinants to estimate mean percent concentration changes. For a subset of 327 children, we also quantified nine PFAS in their mother’s serum collected at the same visit and computed Spearman correlation coefficients ( r sp ) between maternal and child PFAS concentrations. During 2009–2017, child serum concentrations of all nine PFAS decreased by 6–25% annually. Several PFAS concentrations were higher among non-Hispanic white children and those with highly educated parents. Most maternal and child PFAS concentrations were moderately correlated ( r sp = 0.13–0.39), with a strong correlation for N -methyl perfluorooctane sulfonamido acetic acid ( r sp = 0.68). Breastfeeding duration appeared to contribute to higher child and lower maternal PFAS concentrations, resulting in relatively weak correlations between maternal and child PFAS concentrations for samples collected in early childhood. Considering that more than half of our study children had neurodevelopmental concerns, the generalizability of our findings might be limited.
Language: English
Subfield: Environmental Chemistry
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: U.S. Environmental Protection Agency, New York State Department of Health, New York State Department of Health - Wadsworth Center, National Institutes of Health, Centers for Disease Control and Prevention, University of California, Davis, University at Albany, NIH Office of the Director, National Institute of Environmental Health Sciences, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLES, Exposure to Perfluorinated Compounds and Risk for Autism Spectrum Disorders, G1894438544, G2043772298, National Exposure Assessment Laboratory at Emory, Wadsworth Center's Human Health and Exposure Analysis Resource (WC-HHEAR), G3300389418, MIND Institute Intellectual and Developmental Disabilities Research Center, Autism Risk, Prenatal Environmental Exposures, and Pathophysiologic Markers, G4950536974, Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence, MIND Institute Intellectual and Developmental Disabilities Research Center, G666309520, G7006925568, G7073623217, G778889757, The CHARGE Study Phase II: A Multifactorial Approach to Autism Etiology, UC Davis Environmental Health Sciences Core Center, Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence, Human Health Exposure Analysis Resource (HHEAR) Data Center
OpenAlex ID: W4391694779