Work

B-cell ALL with SOX11 gene amplification associates with a worse outcome

Year: 2024

Type: article

Abstract: Copy number variation (CNV) of certain genes in pediatric Acute Lymphoblastic Leukemia (ALL) impacts gene expression levels. Here, we aimed to investigate the potential prognostic utility of CNVs in pediatric B-ALL and T-ALL. Using genomics files representing cases from the TARGET-ALL-P2 dataset, genes commonly involved in ALL development were analyzed for CNVs. Case IDs representing increased copy numbers for SOX11, PDGFRB, and MDK represented a worse overall survival probability specifically for B-ALL (logrank p=0.021, p=0.0052, p=0.019, respectively). These data support the continued investigation of using CNVs for clinical prognostic biomarkers for pediatric B-ALL

Source: Cell Cycle

DOI: 10.1080/15384101.2024.2306756

Authors: George Angelakakis, Mallika Varkhedi, Toriana R. Dabkowski, Michael J. Diaz, Michelle Yeagley, George Blanck

Institutions: University of South Florida, University of Pittsburgh Medical Center, Moffitt Cancer Center

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4391771762