Work

A mathematical model of ENaC and Slc26a6 regulation by CFTR in salivary gland ducts

Year: 2024

Type: article

Abstract: This paper describes a salivary gland mathematical model simulating the ion exchange between saliva and the salivary gland duct epithelium. The novelty lies in the implementation of CFTR regulating ENaC and Slc26a6 in a CFTR knockout gland. By reproducing the experimental saliva measurements in wild-type and CFTR knockout glands, the model shows that CFTR regulates ENaC and Slc26a6 anion exchanger in salivary glands. The method could be used to understand the various cystic fibrosis phenotypes.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00168.2023

Authors: Shan Su, Amanda Wahl, John Rugis, Vinod Suresh, David I. Yule, James Sneyd

Institutions: University of Auckland, University of Rochester

Language: English

Topic: Salivary Gland Disorders and Functions

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Institute of Dental and Craniofacial Research

Awards: G1863379687, G238069952, G5206180421, An experimental/computational approach for understanding salivary fluid secretion