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Quality of life following surgery for head and neck cancer: Evidence from ACRIN 6685

Year: 2024
Type: article
Abstract: BACKGROUND: This study examined the trajectory of health-related quality of life (HRQoL) for patients with clinical stage N0 HNSCC enrolled in ACRIN 6685 who underwent elective neck dissection(s). METHODS: HRQoL of 230 patients in the ACRIN 6685 trial was measured prospectively up to 2 years following surgery using the University of Washington Quality of Life instrument. RESULTS: General Health Within the Last 7 Days did not differ significantly from baseline at any follow-up. General Health Relative to Before Cancer fell significantly by 5.8 points following surgery (p = 0.048), and then returned to 3.0 points above baseline at 1 year (p = 0.65). For Overall Quality of Life, HRQoL fell significantly by 4.3 points following surgery (p = 0.031) and then returned to levels not significantly different from baseline. CONCLUSIONS: Patients with stage N0 HNSCC experience significant declines in HRQoL immediately following surgery, including neck dissection, which recovers to near or better than baseline within 1-2 years.
Source: Head & Neck
DOI: 10.1002/hed.27673
Authors: Christopher S. Hollenbeak, Fenghai Duan, Rathan M. Subramaniam, Alexander Taurone, JoRean Sicks, Val J. Lowe, Brendan C. Stack
Institutions: Pennsylvania State University, Brown University, Duke University, University of Otago, The University of Notre Dame Australia, Mayo Clinic, SIU Medicine
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,760
Awards: G1881030900, ECOG-ACRIN Network Group Operations Center, G2819266960, G4441357666, ECOG-ACRIN NCORP Research Base, Biostatistics Data Management Center for ACRIN, G595549979, G6585845336, G6705915398, ECOG-ACRIN Network Group Statistics and Data Management Center, G6952446453, G8220656038
OpenAlex ID: W4391822543
FWCI: 1.63
Cites: 46
Cited by: 4
Related to: 10