Controllable Double Difluoromethylene Insertions into S−Cu Bonds: (Arylthio)tetrafluoroethylation of Aryl Iodides with TMSCF2Br
Year: 2024
Type: article
Abstract: A new method of constructing “ArSCF2CF2Cu” from ArSCu and TMSCF2Br (TMS=trimethylsilyl) has been developed. The cross‐coupling reactions of the obtained “ArSCF2CF2Cu” with diverse aryl iodides (Ar′I) provide an efficient access to Ar′CF2CF2SAr. Mechanistic studies demonstrate that the “ArSCF2CF2Cu” species were generated through controllable double difluoromethylene insertions into ArS−Cu bonds rather than the 1,2‐addition of ArSCu to tetrafluoroethylene.
Authors: Shitao Pan, Qiqiang Xie, Xiu Wang, Rumin Huang, Yuhao Lu, Chuanfa Ni, Jinbo Hu
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4391845289