Work

Re-evaluating early-onset OSCC in Africa: findings of minimal cumulative incidence

Year: 2024

Type: article

Abstract: We read Arnold et al's article[1] with interest and wanted to extend this work to Africa.High incidence of esophageal squamous cell carcinoma (ESCC) has been reported in African countries from Kenya to South Africa[2] where early-onset (age < 45 years) ESCC accounts for 30% of cases in the region.As such, we examined the cumulative lifetime and age-specific incidences of ESCC in Africa.We identified patients with ESCC in 3 major African cancer registries, using the 2013-2017 Cancer Incidence in Five Continents Volume XII (CI5-XII) database and calculated the age-specific, cumulative lifetime, and cumulative early-onset incidence of early-onset ESCC, all of which will allow us to account for the underlying age structure of the population.We identified 1,022 patients diagnosed with ESCC between 2013 and 2017, of which 47.2% (n=482) were females and 12.3% (n=126) were < 45 years old consistent with early-onset ESCC (Figure 1).Region-level proportions of early-onset ESCC cases varied from 7.6% (26/340) in Eastern Cape, South Africa, to 15.6% (60/384) in Nairobi, Kenya.The cumulative lifetime incidence and cumulative incidence[3] of early-onset ESCC were 1,508 and 33 cases per 100,000 person-year, respectively, and early-onset ESCC only accounted for 2.2% of cumulative lifetime incidence (Table 1 and Supplemental Table 1).We performed similar analyses with data from the United States and the United Kingdom -England; early onset ESCC was 1.5% and 1.1% of all cases, respectively [3].The associated early onset proportions of cumulative incidences were 0.39% and 0.28%, respectively

Source: Gut

DOI: 10.1136/gutjnl-2023-331687

Authors: Mohamed Noureldin, Joel H Rubenstein, Brooke Kenney, Akbar K Waljee