Work

Supplementary Figure S2 from Pim Kinase Inhibitors Increase Gilteritinib Cytotoxicity in FLT3-ITD Acute Myeloid Leukemia Through GSK-3β Activation and c-Myc and Mcl-1 Proteasomal Degradation

Year: 2024

Type: supplementary-materials

Abstract: Concurrent Pim and FLT3 inhibitor treatment inhibits AKT, but GSK-3β activation, c-Myc and Mcl-1 downregulation and apoptosis induction are independent of AKT inhibition as well as ERK inhibition.

DOI: 10.1158/2767-9764.25233485

Authors: Jonelle K. Lee, Aditi Chatterjee, Mario Scarpa, Christopher M. Bailey, Sandrine Niyongere, Prerna Singh, Moaath K. Mustafa Ali, Shivani Kapoor, Yin Wang, Giovannino Silvestri, Maria R. Baer

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4391883909

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