Work

EncoMPASS: An encyclopedia of membrane proteins analyzed by structure and symmetry

Year: 2024

Type: article

Abstract: Protein structure determination and prediction, active site detection, and protein sequence alignment techniques all exploit information about protein structure and structural relationships. For membrane proteins, however, there is limited agreement among available online tools for highlighting and mapping such structural similarities. Moreover, no available resource provides a systematic overview of quaternary and internal symmetries, and their orientation relative to the membrane, despite the fact that these properties can provide key insights into membrane protein function and evolution. Here, we describe the Encyclopedia of Membrane Proteins Analyzed by Structure and Symmetry (EncoMPASS), a database for relating integral membrane proteins of known structure from the points of view of sequence, structure, and symmetry. EncoMPASS is accessible through a web interface, and its contents can be easily downloaded. This allows the user not only to focus on specific proteins, but also to study general properties of the structure and evolution of membrane proteins.

Source: Structure

DOI: 10.1016/j.str.2024.01.011

Authors: Antoniya A. Aleksandrova, Edoardo Sarti, Lucy R. Forrest

Institutions: National Institutes of Health, National Institute of Neurological Disorders and Stroke, ABS: Algorithmes et Biologie Structurale

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $9,350

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke