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Beyond waste: understanding urine’s potential in precision medicine

Year: 2024
Type: review
Abstract: Urine-derived stem cells (USCs) are a promising source of stem cells for cell therapy, renal toxicity drug testing, and renal disease biomarker discovery. Patients' own USCs can be used for precision medicine. In this review we first describe the isolation and characterization of USCs. We then discuss preclinical studies investigating the use of USCs in cell therapy, exploring the utility of USCs and USC-derived induced pluripotent stem cells (u-iPSCs) in drug toxicity testing, and investigating the use of USCs as biomarkers for renal disease diagnosis. Finally, we discuss the challenges of using USCs in these applications and provide insights into future research directions. USCs are a promising tool for advancing renal therapy, drug testing, and biomarker discovery. Further research is needed to explore their potential.
Authors: Pengfei Yu, Carol Christine Bosholm, Hainan Zhu, Zhongping Duan, Anthony Atala, Yuanyuan Zhang
Language: English
Subfield: Genetics
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $7,030
Awards: G1271233140, G2804753821, G3844158083, Silk Fibers-Assisted 3D System for Large-Scale Culture of Human Urine-Derived Stem Cells Suitable for Late Mitotoxicity Testing, Stem Cell Therapy Combined with Growth Factors for Stress Urinary Incontinence, G9000126107
OpenAlex ID: W4391900218
FWCI: 2.87
Cites: 132
Cited by: 22
Related to: 10