Work

Sex Differences in the Association of Multiethnic Genome-Wide Blood Pressure Polygenic Risk Score With Population-Level Systolic Blood Pressure Trajectories

Year: 2024

Type: article

Study design: Observational Study

Abstract: Risk Score; Sex Differences Hypertension, a highly heritable trait and the primary modifiable risk factor for cardiovascular disease, affects nearly half of the US population.1,2 Even though the prevalence of hypertension is higher in males, the age-associated increase in systolic blood pressure (SBP) is more rapid in females.3 Genetic determinants of BP may partly explain the observed sex-associated differences in the SBP trajectory.This study aimed to examine the contribution of the underlying genetic architecture to the sex-associated differences in population-level SBP trajectories in a pooled multi-ancestry US cohort.

Source: Circulation Genomic and Precision Medicine

DOI: 10.1161/circgen.123.004515

Authors: Naman S. Shetty, Akhil Pampana, Nirav Patel, Krishin Yerabolu, Gnyata Patel, Marguerite R. Irvin, Pradeep Natarajan, Henry J. Lin, Xiuqing Guo, Stephen S. Rich, Jerome I. Rotter, Peng Li, Garima Arora, Pankaj Arora

Institutions: University of Alabama at Birmingham, UAB Medicine, Broad Institute, Harvard University, Massachusetts General Hospital, Massachusetts Institute of Technology, The Lundquist Institute, Harbor–UCLA Medical Center, University of Virginia, Birmingham VA Medical Center

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences

Awards: MESA, G1409423729, G1539384734, G1686417863, G1803853571, Wake Forest Clinical and Translational Science Award, G2262782284, MESA, G2580996367, MESA, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G3570589137, G3647016462, G3687594596, MESA, G399481048, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), G4512137732, G4563812999, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA, G5088122703, G5108002584, G514410172, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, G5787256936, CHARGE consortium: omics discovery for CVD and aging phenotypes, Race, Natriuretic Peptides and Physiological Perturbations, G6095866717, G6359107525, Institute for Clinical and Translational Research, MESA, G6514094751, MESA, Clinical and Translational Science Award, G8761005068, Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological Study, Whole genome sequences in ethnically diverse individuals to comprehensively characterize the genetic mechanisms of dyslipidemias, Diabetes Research Center (DRC), Mechanisms of Hypertension and Cardiovascular Diseases, Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood Pressure, UCLA Clinical and Translational Science Institute, The Effects of Neprilysin Inhibition on Cardiometabolic Health in Black Individuals

OpenAlex ID: W4391943435

FWCI: 0.529

Cites: 5

Cited by: 2

Related to: 10