Work

The Reign of Follistatin in Tumors and Their Microenvironment: Implications for Drug Resistance

Year: 2024

Type: review

Abstract: Follistatin (FST) is a potent neutralizer of the transforming growth factor-β superfamily and is associated with normal cellular programs and various hallmarks of cancer, such as proliferation, migration, angiogenesis, and immune evasion. The aberrant expression of FST by solid tumors is a well-documented observation, yet how FST influences tumor progression and therapy response remains unclear. The recent surge in omics data has revealed new insights into the molecular foundation underpinning tumor heterogeneity and its microenvironment, offering novel precision medicine-based opportunities to combat cancer. In this review, we discuss these recent FST-centric studies, thereby offering an updated perspective on the protean role of FST isoforms in shaping the complex cellular ecosystem of tumors and in mediating drug resistance.

Source: Biology

DOI: 10.3390/biology13020130

Authors: Jennifer Sosa, Akinsola Oyelakin, Satrajit Sinha

Institutions: University at Buffalo, State University of New York, Seattle Children's Hospital, Seattle Children's Research Institute

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,069