Work

Are carfentanil and acrylfentanyl naloxone resistant?

Year: 2024

Type: article

Abstract: The rapid rise in deaths since 2012 due to opioid poisoning is correlated with the proliferation of potent synthetic opioid agonists such as fentanyl, acrylfentanyl, and carfentanil. The efficacy of frontline antidotes such as naloxone in reversing such poisoning events has been questioned, and the possibility of naloxone-resistant synthetic opioids has been raised. In this manuscript, we applied in vitro techniques to establish the median effective inhibitory concentrations for fentanyl, acrylfentanyl, and carfentanil and subsequently evaluate naloxone’s ability to reverse agonist–receptor interactions.

Source: Frontiers in Psychiatry

DOI: 10.3389/fpsyt.2024.1359851

Authors: Michael G. Feasel, Theodore S. Moran, Boyle C. Cheng, Saadyah Averick

Institutions: Defense Advanced Research Projects Agency, United States Army Combat Capabilities Development Command, U.S. Army Combat Capabilities Development Command Chemical Biological Center, Allegheny Health Network

Language: English

Topic: Opioid Use Disorder Treatment

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295