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FIGURE 5 from NRF2 Activation in Trp53;p16-deficient Mice Drives Oral Squamous Cell Carcinoma

Year: 2024

Type: other

Abstract: NRF2 activity in human OSCC. TP53, CDKN2A, and NRF2 pathway mutational profiles from 268 HPV—oral cavity squamous cell carcinoma in TCGA. A, Waterfall plot—relative frequency and mutational classes. Color—mutational class. B, Kaplan–Meier plot—disease specific survival of the 254 patients with HPV—oral cavity squamous cell carcinoma with available outcomes data, stratified by NRF2 pathway alteration status. Red—Altered NRF2 pathway. Blue—wild-type NRF2 pathway. P value represents log-rank test. HR—hazard ratio with 95% confidence interval.

DOI: 10.1158/2767-9764.25259856

Authors: Samera H. Hamad, Rani S. Sellers, Nathan Wamsley, Paul Zolkind, Travis P. Schrank, Michael B. Major, Bernard E. Weissman

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4392004710

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