FIGURE 4 from NRF2 Activation in Trp53;p16-deficient Mice Drives Oral Squamous Cell Carcinoma
Year: 2024
Type: other
Abstract: Targeted proteomic analyses of oral cavity tissues from CP and CPN mice. A, Heat map of protein expression from oral tissues of CP (K14-CreERTAM2; p16−/−; p53−/−) and CPN (K14-CreERTAM2; p16−/−; p53−/−; NRF2E79Q/WT) mice, with columns normalized by Z-scores; protein abundances were measured by IS-PRM. See also Supplementary Table S5. B, PCA plot from protein abundances shown in A; the first two principal components explained 35% and 27% of the total variance respectively. C, Plot of the NRF2 score in CP and CPN mice. The score was calculated using 10 NRF2 targets within the first principal component. D, Correlation of the NQO1 protein expression with the NRF2 pathway score. E, Correlation of the SRXN1 protein expression with the NRF2 pathway score. F, Correlation of the IL36G protein expression with the NRF2 pathway score. For correlations of all proteins correlated with the NRF2 score, see Supplementary Fig. S4. G, Box-and-whisker plots of protein abundance in CP and CPN oral cavity tissues. For box-and-whisker plots of abundance for all proteins, see Supplementary Fig. S5. Adjusted P values were calculated with a Mann–Whitney U test. The normal tissue from the oral cavity of the CPN mice showed hyperplasia with hyperkeratosis as shown in Fig. 2B.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4392017688