Year: 2024
Type: article
Abstract: We introduce an allostery-mimetic building block model for the self-assembly of 3D structures. We represent the building blocks as patchy particles, where each binding site (patch) can be irreversibly activated or deactivated by binding of the particle's other controlling patches to another particle. We show that these allostery-mimetic systems can be designed to increase yields of target structures by disallowing misassembled states and can further decrease the smallest number of distinct species needed to assemble a target structure. Next, we show applications to design a programmable nanoparticle swarm for multifarious assembly: a system of particles that stores multiple possible target structures and a particular structure is recalled by presenting an external trigger signal. Finally, we outline a possible pathway for realization of such structures at nanoscale using DNA nanotechnology devices.
Source: The Journal of Chemical Physics
DOI: 10.1063/5.0191282
Authors: Joshua Evans, Petr Šulc
Institutions: Arizona State University, Technical University of Munich
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Award: Programmable Nanomatter
OpenAlex ID: W4392050335