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FIGURE 4 from Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor–positive Breast Cancer

Year: 2024

Type: other

Abstract: Expanded CD8+ T cells demonstrate antigen-specific cytotoxicity. T2 cells were pulsed with corresponding peptides and labeled with calcein-AM. Cytotoxicity was determined by a standard calcein-AM release assay. Wildtype-1 (A), E380Q (B), Wildtype-2 (C), Y537S (D), D538G (E). Non-pulsed T2 cells were used as negative controls. Statistical significance was determined via unpaired Student t test. Data represent the average of three to four experiments from separate healthy female donors run in triplicate. *, P < 0.05; ***, P < 0.001.

DOI: 10.1158/2767-9764.25266561

Authors: Jonathan Goldberg, Na Qiao, Jennifer L. Guerriero, Brett Gross, Yagiz Meneksedag, Yoshimi F. Lu, Anne V. Philips, Tasnim Rahman, Funda Meric-Bernstam, Jason Roszik, Ken Chen, Rinath Jeselsohn, Sara M. Tolaney, George E. Peoples, Gheath Alatrash, Elizabeth A. Mittendorf

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4392058575

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