Work

Bacteriophage-based particles carrying the TNF-related apoptosis-inducing ligand (TRAIL) gene for targeted delivery in hepatocellular carcinoma

Year: 2024

Type: article

Abstract: gene to HCC cells resulting in the production of tmTRAIL from transduced cells and subsequently induced apoptotic death of HCC cells. This tumour-targeted particle can be an excellent candidate for the targeted gene therapy of HCC.

Source: Nanoscale

DOI: 10.1039/d3nr05660k

Authors: Pattaralawan Sittiju, Benjawan Wudtiwai, Aitthiphon Chongchai, Amin Hajitou, Prachya Kongtawelert, Peraphan Pothacharoen, Keittisak Suwan

Institutions: Imperial College London, Chiang Mai University

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Cancer Research UK, CHILDREN with CANCER UK, Royal Golden Jubilee (RGJ) Ph.D. Programme, Medical Research Council

Awards: G195294867, G3262188047, G3543990232, G4366704552, G5481619637, Characterisation of a novel phage-guided gene delivery vector and investigation of its gene therapy efficacy against metastatic cancer.

OpenAlex ID: W4392113523

FWCI: 2.511

Cites: 56

Cited by: 12

Related to: 10