Work

PC4: A new regulator of cyclin D1 transcript levels

Year: 2024

Type: article

Abstract: The expression of cyclin proteins is tightly regulated during the cell cycle, to allow precise activation of cyclin-dependent kinases. In this issue, Pan et al. (https://doi.org/10.1083/jcb.202308066) identify an RNA-binding protein, PC4, as a regulator of cyclin D1 mRNA stability in hepatocellular carcinoma cells. This study provides a new mechanism regulating the levels of a key cell cycle protein, cyclin D1, in human cells.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202401056

Authors: Anne Fassl, Piotr Sicinski

Institutions: Goethe University Frankfurt, University Hospital Frankfurt, Frankfurt Cancer Institute, Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Deutsche Krebshilfe, National Institutes of Health, National Cancer Institute