Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change
Year: 2024
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Individuals in socioeconomically disadvantaged neighborhoods exhibit increased risk for impaired cognitive function. Whether this association relates to the major dementia-related neuropathologies is unknown. METHODS: This cross-sectional study included 469 autopsy cases from 2011 to 2023. The relationships between neighborhood disadvantage measured by Area Deprivation Index (ADI) percentiles categorized into tertiles, cognition evaluated by the last Mini-Mental State Examination (MMSE) scores before death, and 10 dementia-associated proteinopathies and cerebrovascular disease were assessed using regression analyses. RESULTS: Higher ADI was significantly associated with lower MMSE score. This was mitigated by increasing years of education. ADI was not associated with an increase in dementia-associated neuropathologic change. Moreover, the significant association between ADI and cognition remained even after controlling for changes in major dementia-associated proteinopathies or cerebrovascular disease. DISCUSSION: Neighborhood disadvantage appears to be associated with decreased cognitive reserve. This association is modified by education but is independent of the major dementia-associated neuropathologies.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.13736
Institutions: University of Pennsylvania, University of Michigan
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
Awards: Development of a Mobile Cognitive App for Detecting and Monitoring Change in Preclinical Alzheimer's Disease, Center On Alpha-synuclein Strains In Alzheimer Disease & Related Dementias, From cells to complex syndromes: using networks to understand heterogeneity in TDP-related frontotemporal degeneration and aging, G4934550136, Loss of VCP Function in Frontotemporal Lobar Degeneration, Loss of VCP Function in Frontotemporal Lobar Degeneration, Structural biology and molecular biophysics training program, Penn Alzheimer's Disease Research Center (ADRC)
OpenAlex ID: W4392132268