Year: 2024
Type: article
Abstract: Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes are multifactorial and complex, and increasing evidence suggests a dynamic interplay between genes and the environment, emphasizing the importance of identifying and understanding the role of lifelong exposures, known as the exposome, on the nervous system. This review provides an overview of recent advances toward defining neurodegenerative disease exposomes, focusing on Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. We present the current state of the field based on emerging data, elaborate on key themes and potential mechanisms, and conclude with limitations and future directions. ANN NEUROL 2024;95:635-652.
Source: Annals of Neurology
DOI: 10.1002/ana.26897
Institution: University of Michigan
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,300
Funders: Alzheimer's Association, University of Michigan, Sinai Medical Staff Foundation, National Institutes of Health, Centers for Disease Control and Prevention, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences
Awards: G301048564, G3807476488, G4392219874, LINKING LONG-TERM AIR POLLUTION EXPOSURE WITH INFLAMMATION, ALS RISK, AND DISEASE PROGRESSION, Developing novel strategies for personalized treatment and prevention of ALS: Leveraging the global exposome, genome, epigenome, metabolome, and inflammasome with data science in a case/control cohort, METABOLOMIC SIGNATURES LINKING ALS TO PERSISTENT ORGANIC POLLUTANT EXPOSURES, G9000140043, G9000237136, Michigan Diabetes Research Center (MDRC), Mapping and modeling interneuron dysfunction in Alzheimer’s Disease
OpenAlex ID: W4392192160