Work

A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection

Year: 2024

Type: article

Abstract: T helper 17 cells. Healthy human individuals can elicit LafB-specific immune responses, indicating LafB antigenicity in humans. Collectively, these findings present a universal pneumococcal vaccine antigen that remains effective following influenza infection.

Source: Cell Host & Microbe

DOI: 10.1016/j.chom.2024.02.002

Authors: Xue Liu, Laurye Van Maele, Laura Matarazzo, Daphnée Soulard, Vinicius Alves Duarte da Silva, Vincent de Bakker, Julien Dénéréaz, Florian P. Bock, Michael Taschner, Jinzhao Ou, Stephan Gruber, Victor Nizet, Jean-Claude Sirard, Jan-Willem Veening

Institutions: Shenzhen University, Shenzhen University Health Science Center, University of Lausanne, Centre National de la Recherche Scientifique, Inserm, Université de Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, University of California San Diego, Centre Hospitalier Universitaire de Lille

Language: English

Topic: Pneumonia and Respiratory Infections

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $9,350

Funders: National Science Foundation, Institut National de la Santé et de la Recherche Médicale, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Université de Lausanne, Shenzhen University, H2020 European Research Council

Awards: Development of CRISPRi-seq for Group A Streptococcus, G2374388372, G4211055667, scCRISPRi-seq and advanced microscopy to identify key virulence factors and heterogeneous host responses during Streptococcus pneumoniae infection, G6023213073, The role of cell-to-cell variability in pneumococcal virulence and antibiotic resistance

OpenAlex ID: W4392203333

FWCI: 4.154

Cites: 86

Cited by: 16

Related to: 10