Tracking of serum lipid levels from childhood to adulthood: Systematic review and meta-analysis
Year: 2024
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: BACKGROUND AND AIMS: The utility of lipid screening in pediatric settings for preventing adult atherosclerotic cardiovascular diseases partly depends on the lifelong tracking of lipid levels. This systematic review aimed to quantify the tracking of lipid levels from childhood and adolescence to adulthood. METHODS: We systematically searched MEDLINE, Embase, Web of Science, and Google Scholar in March 2022. The protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO; ID: CRD42020208859). We included cohort studies that measured tracking of lipids from childhood or adolescence (<18 years) to adulthood (≥18) with correlation or tracking coefficients. We estimated pooled correlation and tracking coefficients using random-effects meta-analysis. Risk of bias was assessed with a review-specific tool. RESULTS: Thirty-three studies of 19 cohorts (11,020 participants) were included. The degree of tracking from childhood and adolescence to adulthood differed among lipids. Tracking was observed for low-density lipoprotein cholesterol (pooled r = 0.55-0.65), total cholesterol (pooled r = 0.51-0.65), high-density lipoprotein cholesterol (pooled r = 0.46-0.57), and triglycerides (pooled r = 0.32-0.40). Only one study included tracking of non-high-density lipoprotein cholesterol (r = 0.42-0.59). Substantial heterogeneity was observed. Study risk of bias was moderate, mostly due to insufficient reporting and singular measurements at baseline and follow-up. CONCLUSIONS: Early-life lipid measurements are important for predicting adult levels. However, further research is needed to understand the tracking of non-high-density lipoprotein cholesterol and the stability of risk classification over time, which may further inform pediatric lipid screening and assessment strategies.
Source: Atherosclerosis
Authors: Oliver Stanesby, Matthew K. Armstrong, Petr Otahal, James P. Goode, Brooklyn J. Fraser, Kazuaki Negishi, Tetsuhiro Kidokoro, Tania Winzenberg, Markus Juonala, Feitong Wu, Rebecca K. Kelly, Bo Xi, Jorma S.A. Viikari, Olli T. Raitakari, Stephen R. Daniels, Grant R. Tomkinson, Costan G. Magnussen
Institutions: University of Tasmania, Baker Heart and Diabetes Institute, Menzies Institute for Medical Research, University of Iowa, University of South Australia, The University of Sydney, Nepean Hospital, Nippon Sport Science University, University of Turku, Turku University Hospital, The University of Melbourne, Shandong University, Qilu Hospital of Shandong University, University of Colorado Anschutz
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,790
Awards: The long-term effects of child, adolescent, and young adult cholesterol levels on future cardiovascular disease., The protective effects of physical activity in low birthweight infants, Classroom environment that facilitate children's communication: an intervention study using a standing desk
OpenAlex ID: W4392203516